General Information

Welcome to this tool which allows to perform the prediction of mutations in the initiation codon. After introducing the input, a message will appear on screen indicating whether the mutation is BENIGN or DELETERIOUS and a percentage showing how sure it is of said prediction. More information about this predictor and how it was developed can be found in: https://github.com/JavierCastellD/InitiationCodonMutationPredictor.

Input options

There are three possible input options:

Features: introduce the value of each of the features of the predictor: if there is a premature stop codon, status of the reading frame, length percentage of the mutated amino acid, number of ATG in the 5' UTR which are not in phase with the original codon, distance to the alternative initiation codon, and distance to the stop codon.
Sequences: introduce the complementary DNA sequence, the coding region sequence, and the mutated complementary DNA sequence.
Ensembl Transcript: introduce the Ensembl transcript ID and the codon change.

Input your data

Premature Stop Codon

Reading Frame Status

Mutated Sequence Length

Number of Lost Mets in 5' UTR

Met Position

Stop Codon Position

Input your data

CDNA sequence

CDS sequence

Mutated CDNA sequence

Input your data

Ensembl ID

Codon Change: ATG /